About
Lower East Side deli on Orchard Street where every hero is named for someone in the family. The Uncle John is the classic Italian: prosciutto, mortadella, spicy soppressata and provolone with lettuce, roasted peppers, oil and vinegar on a hero roll.
Regina's opened on Orchard Street and now has shops in the East Village and Bed-Stuy too. Order at the counter and mind the bread: some heroes come on the "classic hero" roll, others on stirato. Beyond the Uncle John, the Uncle Jimmy brings prosciutto, spicy soppressata and fresh mozzarella with Calabrian chili spread, and Big Anthony keeps it to mortadella, provolone and mustard.
Address: 27 Orchard St, New York, NY 10002 Phone: (917) 261-5792
Sources (checked 2026-11-11): reginasgrocery.com (Orchard Street, East Village and Bed-Stuy addresses and phones; menu with Uncle John, Uncle Jimmy, Big Anthony; hours; Instagram @ReginasGrocery); EV Grieve, 2026-05-11 (new First Avenue shop, sandwiches named after relatives, "the outpost down on Orchard Street", run by Roman Grandinetti); The Lo-Down, July 2017 ("Regina's Grocery opens at 27 Orchard St").
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Regina's Grocery – Orchard Street
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